Generic Clobex medication side effects include the followin: burning, itching, stinging, dryness and redness can happen around application site but generally fade after a few treatments. Some patients reported signs of stretch marks, acne, unusual hair growth, and skin discoloration. Notify a local physician if these symptoms or swelling and irritation are suffered. It is possible for this drug to be absorbed in the blood stream and result in weight loss, vision problems, tiredness, or increased thirst and urination. Report these conditions immediately.