Some of the side effects that might occur when using generic Depakene include shakiness, nausea, headaches, drowsiness, vomiting, weakness, dizziness, hair loss, abdominal pain, diarrhea or constipation, flu-like symptoms, infections, double vision, insomnia, indigestion or heartburn, blurred vision, nervousness, weight gain, back pain, coordination problems, uncontrollable eye movements, swelling or water retention in the arms, legs, or feet, memory loss (amnesia), ringing in the ears (tinnitus), increased appetite or loss of appetite, fever, emotional problems, weight loss, depression, signs of liver damage, signs of pancreatitis (inflammation of the pancreas), worsening of seizures, unexplained bruising or bleeding, signs of an allergic reaction, and suicidal thinking or behavior.