Side effects of generic Estrace tablets may include chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; sudden numbness or weakness, especially on one side of the body; sudden headache, confusion, problems with vision, speech, or balance; pain or swelling in your lower leg; abnormal vaginal bleeding; pain, swelling, or tenderness in your stomach; jaundice (yellowing of the skin or eyes); or a lump in your breast. Other less serious side effects are more likely to occur when you buy Estrace, such as nausea, vomiting, loss of appetite; swollen breasts; acne or skin color changes; decreased sex drive, impotence, or difficulty having an orgasm; migraine headaches or dizziness; vaginal pain, dryness, or discomfort; swelling of your ankles or feet; depression; or changes in your menstrual periods, break-through bleeding.