The most common side effects involved with this medication are reactions at the area of application. They include blisters, burning, hives, itching, peeling, redness, stinging and swelling. When used for vaginal yeast infections, this medicine can cause increased discharge, including discharge with an unpleasant odor. Women using the cream for this purpose should not use tampons, douches or other vaginal products. Other side effects side effects also may include stomach upset or cramping, nausea, rash, fever and headache.