These medications can act as a sedative and patients should exercise caution when under the influence of these drugs. Driving a vehicle, operating heavy machinery, and other complex motor activities should be avoided while taking these drugs. In addition, use of alcohol or other drugs may increase the sedative effect experienced by users. Your local doctor should be consulted to determine if pheniramine drug is the best solution. Those patients that have any of the following conditions should be sure to mention them during the visit: kidney disease, diabetes, heart disease, emphysema, enlarged prostate, liver disease, glaucoma, high blood pressure, thyroid disease, or chronic bronchitis. In addition, this medication should not be taken if the patient is also taking a monoamine oxidase inhibitor as well.