Simvastatin should be one part of an effort to reduce cholesterol in conjunction with a cholesterol-lowering diet plan. You should avoid drinking alcohol or eating grapefruit when taking simvastatin. If taking simvastatin, seek immediate medical attention if you feel unexplained muscle pain, tenderness or weakness, flu or fever symptoms or dark-colored urine. Simvastatin should never be used when pregnant or breast-feeding. In rare cases, simvastatin can cause the breakdown of skeletal muscle tissue, which can lead to kidney failure. If any of these may be an issue, talk to your doctor before you order generic simvastatin tablets online.