Clomiphene Citrate: Uses, Dosage, Side Effects & Tips

If you’re trying to get pregnant and your doctor mentioned clomiphene citrate, you probably have a lot of questions. Below you’ll find the basics you need to understand this drug, how to take it, and what to watch out for.

How Clomiphene Citrate Works

Clomiphene citrate is a pill that tricks your brain into thinking estrogen levels are low. Your brain then releases more follicle‑stimulating hormone (FSH), which nudges the ovaries to grow and release an egg. In simple terms, it helps jump‑start ovulation for people who don’t ovulate on their own.

Typical Dosage & How to Take It

Most doctors start you on 50 mg once a day for five days, beginning on day 2‑5 of your menstrual cycle. If you don’t ovulate, the dose may be increased to 100 mg or 150 mg in later cycles. Take the tablet with water, with or without food – the key is to take it at the same time each day.

While you’re on clomiphene, your doctor will often schedule an ultrasound around day 10‑12 to see how the follicles are growing. Blood tests for hormone levels may also be done to fine‑tune the dose.

It’s normal to feel a little change in mood or body temperature. Most side effects are mild, but you should know what to expect.

Common side effects include hot flashes, headaches, bloating, and mood swings. Some people notice vision changes like blurred spots – if that happens, call your doctor right away. A small chance of multiple pregnancies (twins or more) exists, so early ultrasound is important.

Serious risks are rare, but ovarian cysts can develop if the dose is too high. If you experience severe abdominal pain, fever, or persistent nausea, seek medical help.

Safety tips:

  • Don’t take more than your doctor prescribes – higher doses don’t guarantee better results and increase side‑effect risk.
  • Avoid taking other fertility drugs unless your doctor says it’s safe.
  • Keep a symptom diary – note any hot flashes, mood changes, or vision issues.
  • Stop the medication if you get a positive pregnancy test; continue only under doctor guidance.

Frequently asked questions:

  • Can I use clomiphene if I’m over 35? Yes, many doctors prescribe it to older patients, but success rates may be lower, so close monitoring is essential.
  • Will it work for everyone? No. About 70‑80 % of people ovulate on the first cycle, but some need other treatments.
  • Does it cause birth defects? Research shows no increase in birth defects when the drug is stopped after ovulation is confirmed.

Bottom line: clomiphene citrate can be a helpful first step in many fertility plans, but it works best when you follow dosing instructions and stay in touch with your healthcare provider. Talk openly with your doctor about any concerns, and you’ll have the best chance of a smooth, successful cycle.

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Written by

Katie Law, Jul, 28 2025